Structural studies of bioactivity in sol-gel-derived glasses by X-ray spectroscopy

Journal of Biomedical Materials Research. Part a
Laura J SkipperR J Newport

Abstract

Extended X-ray absorption fine structure spectroscopy and X-ray absorption near edge structure, X-ray fluorescence spectroscopy, and X-ray powder diffraction have been used to study the local calcium environment in four sol-gel-derived bioactive calcium silicate glasses of the general formula (CaO)(x)(SiO(2))(1-x). The formation of a hydroxyapatite layer on the composition with the highest bioactivity (x = 0.3) with time has been studied, in an in vitro environment, by immersion in simulated body fluid (SBF) at 37 degrees C. The calcium oxygen environment in the four compositions has been shown to be six-coordinate in character. Both the extended X-ray absorption fine structure spectroscopy and X-ray absorption near edge structure show a gradual increase in coordination number and Ca--O bond distance with longer exposure to SBF. X-ray fluorescence show that calcium is quickly lost from the samples on exposure to SBF and the calcium concentration then recovers with time. There is clear evidence that the recovery of calcium content is due to the formation of a CaO-P(2)O(5)-rich layer. Annealing of samples at 650 degrees C shows the presence of what, on the length scales probed by X-ray diffraction, appears to be noncrystalline ca...Continue Reading

References

Sep 1, 1992·Journal of Biomedical Materials Research·C Y KimL L Hench
Jun 1, 1986·Biochemical Society Transactions·D W HukinsS S Hasnain
Oct 1, 1988·Calcified Tissue International·J E HarriesS S Hasnain
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Citations

Nov 24, 2006·Journal of Materials Science. Materials in Medicine·Robert John NewportLarry L Hench
Nov 21, 2008·Journal of Materials Science. Materials in Medicine·H LuQ F Fang
Feb 15, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Julian R JonesLarry L Hench
Dec 15, 2010·Biomaterials·Danielle LaurencinMark E Smith
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Delia S BrauerStefan Habelitz
Feb 22, 2012·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·R A MartinJ R Jones
Feb 22, 2012·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Marta Cerruti
Feb 4, 2011·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J R JonesR J Newport
Sep 1, 2009·Journal of the American Chemical Society·Danielle LaurencinChristian Bonhomme

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