Structural studies of elongation and release factors

Cellular and Molecular Life Sciences : CMLS
C G Noble, H Song

Abstract

The elongation and termination steps of protein synthesis are controlled by elongation and release factors, respectively. Elongation factors deliver the aminoacyl tRNA to the ribosomal A site, ensuring the elongation of the nascent polypeptide chain by one amino acid at a time, while release factors recognize the stop codons and trigger the release of the polypeptide from the ribosome. Recently, high-resolution crystal structures of ribosomes as well as translation factors on and off the ribosome have contributed a great deal to our understanding of the molecular basis of protein synthesis. This review concentrates on recent developments in our understanding of the elongation and termination steps of protein synthesis, particularly the roles of translation factors and their similarities and differences in the eukaryotic cytosol and prokaryotic systems, through a combination of structural and biochemical studies.

Citations

Oct 5, 2010·Nature Structural & Molecular Biology·Liming ChenHaiwei Song
Sep 21, 2012·The Journal of Biological Chemistry·Jonathan N Gonzalez-FloresPaul R Copeland
Sep 15, 2009·Antioxidants & Redox Signaling·Jesse Donovan, Paul R Copeland
May 8, 2009·Molecular Biology of the Cell·Dario O PassosRoy Parker
Jul 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gwendoline Van GoietsenovenVéronique Mathieu
Sep 3, 2011·Microbiology and Molecular Biology Reviews : MMBR·Natalie VerstraetenJan Michiels
Dec 24, 2014·Journal of Proteomics·Giselle Villa Flor BrunoroRubem Figueiredo Sadok Menna-Barreto
Jul 1, 2010·Wiley Interdisciplinary Reviews. RNA·Yuriko Harigaya, Roy Parker
Sep 26, 2013·Journal of Proteomics·C A RamírezC J Puerta
Oct 6, 2009·Biochimica Et Biophysica Acta·Hana SanderováLibor Krásný
Jan 1, 2013·Translation·Carlos E CunhaMarina V Rodnina
Jan 27, 2015·Journal of Structural and Functional Genomics·Tatsuo YanagisawaShigeyuki Yokoyama
Aug 24, 2016·PLoS Neglected Tropical Diseases·Giselle Villa Flor BrunoroRubem Figueiredo Sadok Menna-Barreto
Feb 17, 2017·PLoS Genetics·Jônatas Santos AbrahãoBernard La Scola
Apr 24, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J A Candido-Silva, N Monesi
Aug 1, 2013·Biomolecular Concepts·Jonathan N Gonzalez-FloresPaul R Copeland

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