PMID: 8462551Mar 15, 1993Paper

Structural studies of the O-antigenic polysaccharide of Fusobacterium necrophorum

European Journal of Biochemistry
K HermanssonM M Garcia

Abstract

The O-specific polysaccharide component of the lipopolysaccharide produced by Fusobacterium necrophorum is of the teichoic acid type, with repeating units connected by phosphoric diester linkages. Dephosphorylation of the polysaccharide by treatment with aqueous hydrogen fluoride yielded a carbohydrate composed of a trisaccharide linked to an acidic component. This product, and the polysaccharide, were investigated by chemical methods and 1H-, 13C-, 31P- and 15N-NMR spectroscopy and the former also by fast-atom-bombardment mass spectrometry. It is proposed that the polysaccharide is composed of repeating units having the following structure, in which Fuc represents fucose (6-deoxy-galactose), Am represents an acetamidino group and Sug 2,4-diamino-2,4,6-trideoxy-D-glucose ('bacillosamine') acetylated at the 2-position and acylated with a (S)-3-hydroxybutanoic acid at the 4-position. The acid was identified as a 2-amino-2-deoxy-2-C-methyl-pentonic acid (2-amino-2-methyl-3,4,5-trihydroxypentanoic acid). The configuration of this acid remains to be determined. [formula: see text]

References

Jan 1, 1976·Canadian Journal of Microbiology·K G Johnson, M B Perry
Feb 1, 1975·Infection and Immunity·M M GarciaK A McKay
Jan 1, 1990·Advances in Carbohydrate Chemistry and Biochemistry·B Lindberg
Jan 1, 1987·Advances in Carbohydrate Chemistry and Biochemistry·A Dell
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Feb 1, 1973·Canadian Journal of Microbiology·M M Garcia, K A McKay

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Citations

Apr 16, 2003·European Journal of Biochemistry·Evgeny VinogradovWilliam W Kay
Apr 27, 2001·European Journal of Biochemistry·L L MacLeanW W Kay
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y WangD L Kasper
Aug 21, 2002·The Journal of Biological Chemistry·N Martin YoungChristine M Szymanski
Dec 8, 2020·Carbohydrate Research·Frank St MichaelEvgeny Vinogradov
Sep 15, 1995·Carbohydrate Research·V A ZubkovY S Ovodov
Sep 1, 1996·Progress in Lipid Research·S G Wilkinson
Dec 13, 2003·Carbohydrate Research·Martine Caroff, Doris Karibian

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