PMID: 639795Mar 15, 1978Paper

Structural studies on the D-arabinose-containing lipid A from Rhodospirillum tenue 2761

European Journal of Biochemistry
R N TharanathanH Mayer

Abstract

Structural studies carried out on the isolated free lipid A of Rhodospirillum tenue 2761 revealed a new type of structure for this lipid. The lipid A backbone of 1',6-linked glucosamine disaccharide (central disaccharide) is substituted by three different sugar residues: the non-reducing end of the disaccharide by 4-amino-4-deoxy-L-arabinose 1-phosphate and its reducing end glycosidically by D-arabinofuranose 1-phosphate; further, the reducing glucosamine of the disaccharide is branched to a third glucosamine residue by a 1'',4-glycosidic linkage. The amino and the hydroxyl groups of the central disaccharide are acylated by 3-hydroxydecanoic acid (amide-linked) and palmitic and myristic acids (ester-linked). Neither amino nor hydroxyl groups of the three external sugar residues are acylated. The results suggest the following chemical structure for the lipid A of R. tenue 2761: (formula: see text).

References

May 1, 1977·Journal of Bacteriology·J WeckesserH Mayer
Sep 15, 1976·European Journal of Biochemistry·R E HurlbertI Fromme
May 5, 1970·Biochimica Et Biophysica Acta·G A Adams, P P Singh
Jun 1, 1969·European Journal of Biochemistry·C GalanosO Westphal
Dec 31, 1949·Nature·C S HANES, F A ISHERWOOD

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Citations

Nov 1, 1978·Die Naturwissenschaften·O LüderitzJ Weckesser
Jan 1, 1981·Pharmacology & Therapeutics·O LüderitzE T Rietschel
Oct 1, 1978·European Journal of Biochemistry·R E HurlbertH Mayer
Oct 17, 1983·European Journal of Biochemistry·P V SalimathH Mayer
Dec 1, 1983·European Journal of Biochemistry·O HolstH Mayer
Sep 2, 1985·European Journal of Biochemistry·N Dalla VeneziaG Michel
Apr 1, 1989·European Journal of Biochemistry·J H KraussH Mayer
Aug 15, 1994·European Journal of Biochemistry·I M HelanderU Seydel
Jan 1, 1984·The American Journal of Emergency Medicine·E T RietschelU Schade
Nov 1, 1986·Scandinavian Journal of Immunology·I FabreC Cocito
Apr 1, 1981·European Journal of Biochemistry·K W BroadyO Lüderitz
Mar 21, 2007·The Journal of Biological Chemistry·Abigail ClementsRichard A Strugnell
Sep 1, 1996·Progress in Lipid Research·S G Wilkinson
Jan 1, 1981·Journal of Bacteriology·J Radziejewska-LebrechtJ Weckesser

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