Structurally plastic peptide capsules for synthetic antimicrobial viruses

Chemical Science
Valeria CastellettoMaxim G Ryadnov

Abstract

A conceptual design for artificial antimicrobial viruses is described. The design emulates viral assembly and function to create self-assembling peptide capsules that promote efficient gene delivery and silencing in mammalian cells. Unlike viruses, however, the capsules are antimicrobial, which allows them to exhibit a dual biological function: gene transport and antimicrobial activity. Unlike other antimicrobials, the capsules act as pre-concentrated antimicrobial agents that elicit rapid and localised membrane-disrupting responses by converting into individual pores at their precise landing positions on membranes. The concept holds promise for engineering virus-like scaffolds with biologically tuneable properties.

References

May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A G CochranM A Starovasnik
Mar 9, 2006·Nature Reviews. Drug Discovery·Enrico MastrobattistaDaan J A Crommelin
May 13, 2006·Science·Trevor Douglas, Mark Young
Dec 14, 2006·Angewandte Chemie·Maxim G Ryadnov
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·David PapapostolouDerek N Woolfson
May 31, 2008·Nanomedicine·Iftach Yacoby, Itai Benhar
Jul 4, 2008·Nature Structural & Molecular Biology·Stephen C Harrison
Oct 30, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Laurence CrombezGilles Divita
Dec 4, 2008·Fundamental & Clinical Pharmacology·Sylvain GoutellePascal Maire
Nov 21, 2009·Nano Letters·Michel T DedeoMatthew B Francis
Dec 18, 2010·Macromolecular Bioscience·Baptiste Lamarre, Maxim G Ryadnov
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sergey G TarasovNadya I Tarasova
Nov 1, 2012·Journal of the American Chemical Society·Jaeyoung PaiInjae Shin
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paulina D RakowskaMaxim G Ryadnov
Oct 24, 2013·Nature Materials·Rosemary KanastyDaniel Anderson
Nov 16, 2013·Nature Chemical Biology·Ashley L HilchieRobert E W Hancock
May 16, 2014·Journal of the American Chemical Society·Nilofar FaruquiMaxim G Ryadnov
Aug 26, 2014·Nature Nanotechnology·Armando Hernandez-GarciaRenko de Vries
Nov 13, 2014·Journal of the American Chemical Society·Rong Ni, Ying Chau

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Citations

Dec 24, 2017·Nature Communications·Emiliana De SantisMaxim G Ryadnov
Jun 7, 2018·Chemical Communications : Chem Comm·Kazunori Matsuura
Oct 31, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Hiroshi Inaba, Kazunori Matsuura
Jan 31, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yoko NakamuraKazunori Matsuura
Jun 18, 2017·Organic & Biomolecular Chemistry·Angelo BellaMaxim G Ryadnov
Sep 30, 2017·Nature Communications·Roberto J Brea, Neal K Devaraj
Jul 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kaiqi LongWeiping Wang
Nov 5, 2019·Biochimica Et Biophysica Acta. Biomembranes·Zahra VaeziLorenzo Stella
Jun 18, 2021·Nanoscale·Irene MarzuoliFranca Fraternali
Jul 28, 2018·Biomacromolecules·Julieta M SánchezAntonio Villaverde
Dec 4, 2019·ACS Nano·Ibolya E KepiroMaxim G Ryadnov
Aug 23, 2019·Journal of Chemical Theory and Computation·Irene MarzuoliFranca Fraternali
Jul 8, 2017·ACS Nano·James F RossDerek N Woolfson
Sep 2, 2016·Journal of the American Chemical Society·James E NobleMaxim G Ryadnov
Nov 15, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Lakshmi Priya DattaTapan Kumar Das
Aug 17, 2021·Frontiers in Chemistry·Patrizia JankovićDaniela Kalafatovic
Feb 9, 2018·ACS Synthetic Biology·Jonathan R BurnsMaxim G Ryadnov
Mar 27, 2019·Biomacromolecules·Ian W Hamley
Oct 2, 2021·Faraday Discussions·Carlos H B CruzFranca Fraternali
Oct 26, 2021·Faraday Discussions·Huong T KratochvilWilliam F DeGrado
Aug 25, 2020·Biochimica Et Biophysica Acta. Biomembranes·Katharine HammondBart W Hoogenboom

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Methods Mentioned

BETA
transmission
atomic force microscopy
AFM
circular dichroism
fluorescence microscopy
X-ray
electrophoresis
transfection
transfecting
Fluorescence

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