PMID: 6412962Aug 8, 1983Paper

Structure - function relationships for gamma-substituted glutamate analogues on dentate granule cells

Brain Research
J F KoernerS L Crooks

Abstract

We previously demonstrated in the Schaffer collateral-CA1 region of the hippocampus that bath-applied agonists could be distinguished from antagonists among a group of acidic amino acid analogues by extracellular recording techniques. Here we report the use of the extracellular signs of agonist activity for discerning agonists and antagonists among several gamma-substituted glutamate analogues tested in the perforant path. The two-pathway composition of the perforant path offers the advantage over CA1 in that pathway-specificity, a postulated characteristic of antagonists, may be tested. By extracellular recording, D- and L-homocysteic acid, L-serine-O-sulfate, and L-2-amino-4-(5-tetrazolyl)-butanoic acid [L-glutamate tetrazole] were identified as agonists, and all 4 analogues were more potent than L-glutamate for inhibiting synaptic field potentials. Two previously identified antagonists, L-2-amino-4-phosphonobutyric acid and L-O-phosphoserine, exhibited the pathway-specificity and inhibitory kinetics consistent with properties expected for antagonists; both compounds detected 3 perforant path components with the same rank in sensitivity, suggesting that they are acting on the same set of receptors.

References

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Citations

Aug 1, 1991·Molecular and Chemical Neuropathology·W E KlunkJ W Pettegrew
Aug 20, 1984·Brain Research·M B RobinsonJ F Koerner
Jul 1, 1995·Neurobiology of Aging·R P MasonJ W Pettegrew
Jun 18, 1986·Neuroscience Letters·L M Aanonsen, G L Wilcox
May 1, 1987·Brain Research Bulletin·R K FreundJ M Wehner
Aug 1, 1997·General Pharmacology·C Thomsen
Jan 1, 1990·Medicinal Research Reviews·J J Hansen, P Krogsgaard-Larsen

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