Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity

Biological & Pharmaceutical Bulletin
Y InouyeToshihiro Yamase

Abstract

The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIB and HIV-1SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1HTLVIIIB activity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1HTLV-IIIB activity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1SF-2 to a much higher extent compared with HIV-1HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1HTLV-IIIB activity and the specificity for HIV-1SF-2H might result from differential structural requirements in these functions.

Citations

May 24, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A OgataM Eriguchi
Jul 25, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S MitsuiM Eriguchi
Apr 23, 2017·Bioorganic & Medicinal Chemistry Letters·Shunyi WangYi Zeng
Sep 29, 2011·Small·Georg GeisbergerGreta R Patzke
May 1, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Awatef S AssranUlrich Kortz
May 23, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Georg GeisbergerGreta R Patzke
Apr 6, 2007·Biological & Pharmaceutical Bulletin·Mayumi OdaToshihiro Yamase
Oct 23, 2010·Ecotoxicology and Environmental Safety·Nikolay Strigul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.