Structure-activity relationship of a pyrimidine receptor in the rat isolated superior cervical ganglion

British Journal of Pharmacology
G P Connolly, P J Harrison

Abstract

1. The effects of pyrimidines and purines on the d.c. potential of the rat isolated superior cervical ganglion (SCG) have been examined by a grease-gap technique to determine the structure-activity requirements of the receptor activated by pyrimidines, i.e. a pyrimidinoceptor. 2. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl (ZTP), the pyrimidines, cytidine 5'-triphosphate (CTP), uridine 5'-triphosphate (UTP) and thymidine 5'-triphosphate (TTP) and the purines, adenosine 5'-triphosphate (ATP; in the presence of an A1-purinoceptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (1 microM)), adenosine 5'-O-(3-thiotriphosphate) (ATP gamma S), guanosine 5'-triphosphate (GTP), inosine 5'-triphosphate (1TP) depolarized ganglia in a concentration-dependent manner. The relative order of ZTP and purine 5'-triphosphates in depolarizing ganglia was ZTP > or = ATP gamma S > > ATP > or = ITP = GTP, and for the pyrimidine 5'-triphosphates UTP > TTP > or = CTP. Depolarizations evoked by ATP gamma S were followed by concentration-dependent hyperpolarizations at 100 and 1000 microM. 3. At concentrations of between 0.1 microM and 1 mM, uridine 5'-diphosphate (UDP), uridine 5'-diphosphoglucose (UDPG) and uridine 5'-diphosphoglucuron...Continue Reading

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Citations

Jun 28, 2000·Journal of the Autonomic Nervous System·D A BrownE A Barnard
Jun 4, 1999·Trends in Pharmacological Sciences·G P Connolly, J A Duley
Oct 1, 1993·British Journal of Pharmacology·G P ConnollyF Brown
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R F StachlewitzR G Thurman
Feb 7, 2001·The Journal of Biological Chemistry·J K ChambersG P Livi

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