Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 1

Bioorganic & Medicinal Chemistry Letters
Bénédicte DelouvriéNicolas Warin

Abstract

Potent antagonists of the integrin α(5)β(1), which are RGD mimetics built from tyrosine are described. This letter describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the basic group and the linker between the basic group and the phenyl central core.

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Citations

Oct 30, 2012·Molecular Pharmaceutics·Rajib K GoswamiSubhash C Sinha
Jun 29, 2013·International Journal of Molecular Sciences·Fen WangTian Xie
Oct 3, 2020·Bioorganic & Medicinal Chemistry Letters·Aparna SundaramHyunil Jo

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