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Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain

Bioorganic & Medicinal Chemistry

Jul 24, 2007

Masahiro OnoMorio Nakayama

Abstract

A series of novel chalcones and their related derivatives were synthesized and evaluated as beta-amyloid imaging probes. In the structure-activity relationship of binding affinities to synthetic Abeta(1-42) aggregates, compound 14 displayed the highest binding affinity in vitro. beta-Am...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Ethanol
n-hexane
Derivatives
Tomography, Emission-Computed, Single-Photon
Ethanol Measurement
APP protein, human
Phenyl
Tributyltin
Structure-Activity Relationship
17
Paper Details
References
  • References2
  • Citations11
12

Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain

Bioorganic & Medicinal Chemistry

Jul 24, 2007

Masahiro OnoMorio Nakayama

PMID: 17644339

DOI: 10.1016/j.bmc.2007.06.055

Abstract

A series of novel chalcones and their related derivatives were synthesized and evaluated as beta-amyloid imaging probes. In the structure-activity relationship of binding affinities to synthetic Abeta(1-42) aggregates, compound 14 displayed the highest binding affinity in vitro. beta-Am...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Ethanol
n-hexane
Derivatives
Tomography, Emission-Computed, Single-Photon
Ethanol Measurement
APP protein, human
Phenyl
Tributyltin
Structure-Activity Relationship
17

Related Papers

Paper Details
References
  • References2
  • Citations11
12
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