Structure-activity relationship of lupane-triterpene glycosides from Acanthopanax koreanum on spleen lymphocyte IL-2 and IFN-gamma

Bioorganic & Medicinal Chemistry Letters
Nguyen Xuan NhiemYoung Ho Kim

Abstract

Phytochemical investigation resulted in the isolation of three new lupane-triterpene glycosides acankoreosides M-O (1, 2 and 8) together with eight known lupane-triterpene glycosides (3-7, 9-11) from the leaves of Acanthopanax koreanum (Araliaceae). Their chemical structures were elucidated by mass, 1D and 2D NMR spectroscopy. The effect of eleven lupane-triterpene glycosides on Con A-induced splenolytic production of IL-2 and IFN-gamma were measured as markers of acquired immune responses. Compounds 4, 5, 7, and 11 (5, 25, and 100 microM) significantly increased IFN-gamma and IL-2 release in spleen cells.

References

Jun 22, 1984·Science·D A Cantrell, K A Smith

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Citations

Jan 28, 2014·International Journal of Biological Macromolecules·Yunpeng FanXiaoping Song
Oct 9, 2013·International Journal of Biological Macromolecules·Yunpeng FanXiaoping Song
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xia MaYunpeng Fan
Jun 19, 2012·International Journal of Biological Macromolecules·Ju YuanYi Wu
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Ya Nan SunYoung Ho Kim
Aug 8, 2014·International Journal of Biological Macromolecules·Zhe RenHaibin Zhang
May 18, 2012·Natural Product Reports·Robert A Hill, Joseph D Connolly

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