Structure-activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity

Bioorganic & Medicinal Chemistry
Mitsuo SekineTakuma Sasaki

Abstract

To study the structure-activity relationship of phosmidosine, a variety of phosmidosine derivatives 9a-g were synthesized by condensation of N-diisopropyl N'-(N-tritylprolyl)phosphorodiamidite 6 with appropriately protected nucleoside derivatives 7a-g. As the result, replacement of the 7,8-dihydro-8-oxoadenine base by adenine and 6-N-acetyladenine did not affect the antitumor activity. However, phosmidosine derivatives containing uracil, cytosine, and guanine in place of the 7,8-dihydro-8-oxoadenine base did not show significant activity. A plausible explanation for the selective expression of phosmidosine compared with that of phosmidosine analogs having other amino acids in place of proline is also discussed. These results suggest that phosmidosine serves as an inhibitor of prolyl adenosine 5'-phosphate (prolyl-AMP) to inhibit the peptide synthesis in cancer-related cells.

References

Apr 1, 1991·The Journal of Antibiotics·M UramotoJ A McCloskey
Jun 1, 1984·The Journal of Antibiotics·K IsonoJ A McCloskey
May 11, 2002·The Journal of Organic Chemistry·Tomohisa MoriguchiMitsuo Sekine

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Citations

Jul 15, 2006·Nucleosides, Nucleotides & Nucleic Acids·Haruhiko TaguchiTakuma Sasaki

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