Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 1. Conversion of 5-substituent on oxazolidinone

Chemical & Pharmaceutical Bulletin
R TokuyamaO Nagata

Abstract

A structure-activity relationship (SAR) study on 5-substituted oxazolidinones as an antibacterial agent is described. The oxazolidinones, of which 5-acetylaminomethyl moiety was converted into other functions, were prepared and evaluated for antibacterial activity. Elongation of the methylene chain (8) and conversion of the acetamido moiety into guanidino moiety (12) decreased the antibacterial activity. The replacement of carbonyl oxygen (=O) by thiocarbonyl sulfur (=S) enhanced in vitro antibacterial activity. Especially, compound 16, which had the 5-thiourea group, showed 4-8 stronger in vitro activity than linezolid. Our SAR study revealed that the antibacterial activity was greatly affected by the conversion of 5-substituent.

References

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Citations

May 3, 2007·Chemical & Pharmaceutical Bulletin·Fumiko FujisakiKunihiro Sumoto
Jan 3, 2006·Bioorganic & Medicinal Chemistry Letters·Braj Bhushan LohrayPrashant Kapadnis
Sep 11, 2004·Bioorganic & Medicinal Chemistry·Braj Bhushan LohrayPurvi Pandya
Oct 23, 2004·Bioorganic & Medicinal Chemistry·Yeong Woo JoEung Chil Choi
Oct 27, 2004·European Journal of Medicinal Chemistry·Brijesh Kumar SrivastavaVidya Bhushan Lohray
Jan 15, 2015·Phytotherapy Research : PTR·K Mary Elizabeth GnanambalEdward J K Patterson

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