Jan 1, 1976

Structure-activity relationships among desmethyl derivatives of neuroleptics and antidepressants for substrate specificty to indolethylamine N-methyltransferase from rabbit lung

Psychopharmacology Communications
N Narasimhachari, R L Lin

Abstract

Desmethylperazine (norperazine) and desmethylprochlorperazine (norprochlorperazine), like nor1- and nor2chlorpromazine, are excellent substrates for indolethylamine N-methyltransferase (NMT) and also inhibit the formation of dimethyltryptamine (DMT) from N-methyl-tryptamine (NMT). Nortriptyline and protriptyline, antidepressant compounds which like NMT contain a secondary amino group, also serve as substrates for INMT but lack in inhibitory effect on DMT formation.

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Mentioned in this Paper

Antipsychotic Effect
Perazine Maleate (1: 2)
10-piperazinylpropylphenothiazine
Derivatives
Lung
Structure-Activity Relationship
Protriptyline
NR4A3 gene
Tryptamine
Nortriptyline Assay

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