Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update

Journal of Medicinal Chemistry
Maria ModicaMarcello Leopoldo

Abstract

Serotonin 5-HT7 receptor (5-HT7R) has been the subject of intense research efforts because of its presence in brain areas such as the hippocampus, hypothalamus, and cortex. Preclinical data link the 5-HT7R to a variety of central nervous system processes including the regulation of circadian rhythms, mood, cognition, pain processing, and mechanisms of addiction. 5-HT7R blockade has antidepressant effects and may ameliorate cognitive deficits associated with schizophrenia. 5-HT7R has been recently shown to modulate neuronal morphology, excitability, and plasticity, thus contributing to shape brain networks during development and to remodel neuronal wiring in the mature brain. Therefore, the activation of 5-HT7R has been proposed as a therapeutic approach for neurodevelopmental and neuropsychiatric disorders associated with abnormal neuronal connectivity. This Perspective celebrates the silver jubilee of the discovery of 5-HT7R by providing a survey of recent studies on the medicinal chemistry of 5-HT7R ligands and on the neuropharmacology of 5-HT7R.

References

Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M RuatJ C Schwartz
Mar 3, 1999·Journal of Medicinal Chemistry·C KikuchiM Koyama
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·B PouzetJ Arnt
Mar 22, 2002·British Journal of Pharmacology·Kurt A Krobert, Finn Olav Levy
Oct 24, 2002·Bioorganic & Medicinal Chemistry Letters·Ian T ForbesDavid R Thomas
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A ShapiroRichard Mailman
Jun 19, 2003·British Journal of Pharmacology·David R ThomasIan T Forbes
Nov 18, 2003·Nature Reviews. Neuroscience·Patricia GasparLuc Maroteaux
Feb 18, 2004·Current Drug Targets. CNS and Neurological Disorders·David R Thomas, Jim J Hagan
Mar 10, 2004·The Journal of Pharmacy and Pharmacology·Marcello LeopoldoVincenzo Tortorella
Mar 23, 2004·Current Medicinal Chemistry·M Leopoldo
Apr 14, 2004·The European Journal of Neuroscience·Amanda J RobertsPeter B Hedlund
Feb 18, 2005·The Journal of Pharmacology and Experimental Therapeutics·Chris R GuthrieMark W Hamblin
Jun 7, 2005·Behavioural Brain Research·Georgina S Perez-García, A Meneses
Aug 6, 2005·The Journal of Comparative Neurology·Stéphane DolyMarie Conrath
Aug 16, 2005·Pain·Héctor I Rocha-GonzálezVinicio Granados-Soto
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elena KvachninaEvgeni G Ponimaskin
Dec 13, 2006·Journal of Medicinal Chemistry·Marcin KołaczkowskiAndrzej J Bojarski
Mar 26, 2008·Journal of Medicinal Chemistry·Balázs VolkGyula Simig
Aug 12, 2008·Current Topics in Medicinal Chemistry·Enza LacivitaRoberto Perrone
Mar 31, 2009·Journal of Medicinal Chemistry·Rocío A MedinaMaría L López-Rodríguez

❮ Previous
Next ❯

Citations

Feb 16, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Haroon KhanAnupam Bishayee
Oct 18, 2019·Frontiers in Behavioral Neuroscience·Cristiana CarboneWalter Adriani
Oct 22, 2020·Chronobiology International·Binwen LiuTianjiao Xia
Sep 19, 2019·European Journal of Medicinal Chemistry·Giuseppe RomeoMaria Nunziata Modica
Nov 2, 2019·Neuropharmacology·Elina T L'EstradeMatthias M Herth
Dec 23, 2020·International Journal of Molecular Sciences·Alessandra TempioMarcello Leopoldo
Feb 15, 2021·European Journal of Medicinal Chemistry·Edward OforiSeth Y Ablordeppey
May 26, 2021·Journal of Medicinal Chemistry·Jieon LeeHyunah Choo
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vittorio CanalePaweł Zajdel
Jul 27, 2021·Bioorganic & Medicinal Chemistry Letters·Katarzyna Kucwaj-BryszJadwiga Handzlik
Oct 18, 2019·ACS Medicinal Chemistry Letters·Matthew R PorterJoseph J Topczewski
Sep 15, 2021·Journal of Medicinal Chemistry·Rina KwagHyunah Choo
Jan 16, 2022·Neurobiology of Learning and Memory·Tiantian LiuXiaoping Gu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.