PMID: 3504213Jul 1, 1987Paper

Structure-activity relationships for apomorphine congeners. Conformational energies vs. biological activities

Journal of Computer-aided Molecular Design
I Pettersson, T Liljefors


A series of apomorphine congeners has been studied with respect to their ability to mimic the structural requirements of the dopamine pharmacophore in the potent and stereoselective dopamine receptor agonist (R)-apomorphine. Conformational energies of the mimicking structures calculated by molecular mechanics (MMP2) correlate well with the observed biological activities.


Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TitelerP Seeman
Aug 1, 1979·Journal of Medicinal Chemistry·J G CannonR J Naylor
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Apr 1, 1986·Journal of Medicinal Chemistry·E J Lloyd, P R Andrews
Mar 1, 1973·Journal of Medicinal Chemistry·J G CannonJ P Long
Apr 1, 1972·Journal of Medicinal Chemistry·J G CannonM A Aleem


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Related Concepts

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