PMID: 7540921Feb 1, 1995Paper

Structure-activity relationships in a series of 3-sulfonylamino-2-(1H)-quinolones, as new AMPA/kainate and glycine antagonists

Bioorganic & Medicinal Chemistry
A A CordiJ M Lepagnol

Abstract

This paper describes the design and synthesis of a new class of molecules, the 3-sulfonylamino-2-(1H)-quinolones, which are potent and selective antagonists at both the AMPA/kainate site as well as at the NMDA-associated glycine site. The molecules were characterized by their binding affinities to rat cortical membranes and by electrophysiology on Xenopus oocytes injected with mRNA isolated from rat cerebral cortex. The most potent compound 61 has an IC50 of 0.09 microM for binding at the AMPA/kainate site, and 0.16 microM in oocyte electrophysiology.

References

Nov 7, 1991·Nature·K MoriyoshiS Nakanishi
Aug 1, 1990·Trends in Pharmacological Sciences·R DingledineJ O McNamara
Sep 1, 1987·British Journal of Pharmacology·C DacquetJ Mironneau
Jun 1, 1973·The Journal of Experimental Zoology·R A WallaceM W Sega

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Citations

Nov 8, 2002·Il Farmaco·Alex A CordiPierre Lestage
Nov 24, 1999·Virus Research·S Latvala-Kilby, K Lehto
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wafa RedjdalSamir Messaoudi
Aug 8, 2006·Medicinal Research Reviews·Daniela CatarziFlavia Varano
Mar 25, 2019·Biological Chemistry·Adela Dudić, Andreas Reiner
Jan 17, 2013·ChemMedChem·Christian B M Poulie, Lennart Bunch
Sep 25, 2017·Journal of the American Chemical Society·Yunhe JinHua Fu
Apr 18, 2003·Journal of Medicinal Chemistry·Irina G TikhonovaNikolai S Zefirov

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