PMID: 619146Jan 1, 1978Paper

Structure-activity relationships in antitumor aniline mustards

Journal of Medicinal Chemistry
A PanthananickalA Leo


Quantitative structure-activity relationships (QSAR) have been formulated for the hydrolysis of aniline mustards and their antitumor activity against Walker 256 tumor and L1210 and P388 leukemia. In general, the antitumor activity parallels hydrolysis under the conditions defined by Ross; toxicity (LD50) parallels antitumor efficacy. Chlorambucil is an exception. A most important finding is that ideal lipophilicity for effectiveness against Walker tumor appears to be much higher than for the leukemias which suggests that solid tumors may, in general, require more lipophilic drugs than leukemias.


May 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J C PhillipsG C Hard
Jul 20, 2002·European Journal of Medicinal Chemistry·Lilach HedvatiMilon Sprecher
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Jan 22, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Katleen De WinneEtienne H Schacht

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