Structure-activity relationships in C-terminal fragment analogs of pheromone biosynthesis activating neuropeptide in Helicoverpa zea

Archives of Insect Biochemistry and Physiology
J P KochanskyT G Kempe

Abstract

A number of analogs of the C-terminal hexapeptide of PBAN were prepared and tested in vivo for pheromonotropic activity in Helicoverpa zea. Peptides prepared with longer-chain omega-aminocarboxylic acids (Tyr-6-aminocaproyl-Leu-NH2 and Tyr-7-aminoheptanoyl-NH2) were active at 25 and 2.5 nmol. Acetyl-Pro-Arg-Leu-NH2 was active at 1,000 pmol and represents a new minimum active fragment in the PBAN system. Addition of a bulky, hydrophobic tail (4-octylphenoxyacetyl) to the C-terminal hexapeptide of PBAN gave an analog that was active at all concentrations tested from 1 to 1,000 pmol when injected, had slight oral activity, but had no activity when applied topically. Glu-Tyr-Phe-Ser-Pro-Arg-Leu-NH2 was active at 1,000 but not at 100 pmol; at the latter dose it synergised the activity of 5 pmol of PBAN.

References

Jan 1, 1992·Bioscience, Biotechnology, and Biochemistry·H KuniyoshiG M Holman
Nov 1, 1992·International Journal of Peptide and Protein Research·R J NachmanW F Haddon
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R J NachmanJ A Tainer
Aug 30, 1989·Biochemical and Biophysical Research Communications·A KitamuraA Suzuki
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·R B MerrifieldH G Boman
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·G GuichardS Muller
Jan 1, 1994·Archives of Insect Biochemistry and Physiology·H NagasawaA Suzuki
Jan 1, 1993·Annual Review of Entomology·A K Raina
Jun 15, 1993·Biochemical and Biophysical Research Communications·R J NachmanA Suzuki

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