Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

Bioorganic & Medicinal Chemistry Letters
Rosa ArienzoStephen P Wren

Abstract

A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors.

References

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Feb 13, 2001·The Journal of Clinical Investigation·D S LudwigE Maratos-Flier
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Oct 9, 2002·JAMA : the Journal of the American Medical Association·Katherine M FlegalClifford L Johnson

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Citations

Jun 15, 2005·Bioorganic & Medicinal Chemistry Letters·Tao GuoDoug W Hobbs
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Guillaume J Hervieu
Jul 12, 2007·Chemical Reviews·Jade S BlakeneyDavid P Fairlie
Nov 14, 2007·The Journal of Organic Chemistry·Denise AndersenMike Martinelli
Nov 28, 2006·Journal of Medicinal Chemistry·Francis X TavaresHui-Qiang Zhou

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