Structure-Activity Relationships of GAG Mimetic-Functionalized Mesoporous Silica Nanoparticles and Evaluation of Acyclovir-Loaded Antiviral Nanoparticles with Dual Mechanisms of Action

ACS Omega
Edward C LeeBenjamin P Ross

Abstract

Mesoporous silica nanoparticles (MSNs) are drug delivery agents that are able to incorporate drugs within their pores. Furthermore, MSNs can be functionalized by attachment of bioactive ligands on their surface to enhance their activity, and nanoparticles modified with glycosaminoglycan (GAG) mimetics inhibit the entry of herpes simplex virus (HSV) into cells. In this study, structure-activity relationships of GAGs attached to MSNs were investigated in relation to HSV-1 and HSV-2, and acyclovir was loaded into the pores of MSNs. The sulfonate group was demonstrated to be essential for antiviral activity, which was enhanced by incorporating a benzene group within the ligand. Loading acyclovir into GAG mimetic-functionalized MSNs reduced the viral infection, resulting in nanoparticles that simultaneously target two distinct viral pathways, namely, inhibition of viral entry and inhibition of DNA replication.

References

Jan 1, 1993·Journal of Medical Virology·G B Elion
May 30, 2001·Lancet·R J Whitley, B Roizman
Aug 24, 2001·The Journal of Clinical Investigation·D Shukla, P G Spear
Apr 2, 2004·Cellular Microbiology·Patricia G Spear
May 25, 2004·Antimicrobial Agents and Chemotherapy·Natalia CheshenkoBetsy C Herold
Oct 14, 2004·Journal of the American Chemical Society·Daniela R RaduVictor S-Y Lin
May 6, 2006·Angewandte Chemie·Frank HoffmannMichael Fröba
Apr 14, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Roberta CavalliDavid Lembo
Jun 3, 2009·Expert Review of Anti-infective Therapy·Sarah S WilsonBetsy C Herold
Sep 8, 2009·Nature Chemical Biology·Françoise BaleuxHugues Lortat-Jacob
Mar 17, 2010·Journal of the American Chemical Society·Yu-Shen Lin, Christy L Haynes
Nov 26, 2010·Antiviral Chemistry & Chemotherapy·David Lembo, Roberta Cavalli
May 3, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Zaki G EstephanJoseph B Schlenoff
Jun 13, 2012·Journal of Neuroscience Methods·Alice E McGovernStuart B Mazzone
Jun 16, 2012·Science Translational Medicine·Laura M EnsignJustin Hanes
Jul 17, 2012·Chemical Communications : Chem Comm·Dana Baram-PintoRonit Sarid
Apr 30, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ali NazemiElizabeth R Gillies
Aug 31, 2013·Investigative Ophthalmology & Visual Science·Paul J ParkDeepak Shukla
Oct 1, 2011·Drug Delivery and Translational Research·Sanyog JainNitin K Swarnakar
Nov 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guo-Feng LuoXian-Zheng Zhang

❮ Previous
Next ❯

Citations

Sep 4, 2020·ChemPlusChem·Lili LiangGrzegorz Lisak
Feb 2, 2021·Nano Today·Jiarong ZhouLiangfang Zhang
Jul 25, 2021·International Journal of Molecular Sciences·Cristina CarucciAndrea Salis
Aug 8, 2021·Nanomaterials·Syed Mohammed Basheeruddin AsdaqKatharigatta N Venugopala
Feb 3, 2022·Drug Development and Industrial Pharmacy·Ekaterina S DolininaElena V Parfenyuk

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
transmission
dynamic light scattering
NMR
Assay
X-ray
FCS

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.