Structure-activity relationships of imperialine derivatives and their anticholinergic activity

Planta medica
Atta-Ur-RahmanB Sener

Abstract

In order to check the structure-activity relationship and prepare more potent derivatives of imperialine with anticholinergic activity, imperialinol (2), 3 beta-acetoxyimperialine (3), 3 beta-propionoxyimperialine (4), and 3 beta-butyroxyimperialine (5) were prepared. Compounds 4 and 5 displayed better anticholinergic activity against muscarinic receptors of the heart and brain than imperialine (1). The decrease in activity in 2 showed the importance of the 6-keto functionality in imparting the anticholinergic activity.

Citations

Mar 27, 2003·Phytochemistry·M Nadeem AkhtarYoshisuke Tsuda
Feb 11, 2005·Natural Product Research· Atta-ur-RahmanMasood Parvez
Sep 9, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Qing LinZhirong Zhang
Jul 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li QiaoQingcong Wei
Sep 24, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Qing LinZhirong Zhang

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