Structure-activity relationships of saponins from Gleditsia sinensis in cytotoxicity and induction of apoptosis

Planta medica
Lei ZhongDean Guo

Abstract

Thirteen compounds were isolated from the anomalous fruits of Gleditsia sinensis on the basis of bioassay-guided fractionation. These saponins together with six analogues or related compounds were tested for their cytotoxicities against six tumor cell lines by the MTT method. The induction of apoptosis in HL-60 cells by these compounds was determined through flow cytometric analysis. Some structure-activity relationships in cytotoxicity and induction of apoptosis were identified. The evaluation of the cytotoxicity and the ability to induce apoptosis revealed that some important structural features are required for activity. A valuable model which enables prediction of their activities was established and may be employed for the drug design of new Gleditsia saponin analogues.

Citations

Jan 15, 2013·Journal of Pharmaceutical and Biomedical Analysis·Xiao-Yuan Lian, Zhizhen Zhang
Dec 23, 2009·International Journal of Cancer. Journal International Du Cancer·Ruth ChuSylvia Fong
Nov 13, 2015·Natural Product Research·Chao LiuJin-Yue Sun
Feb 24, 2018·Natural Product Research·Jinqian YuPeng Yang
Apr 16, 2020·Journal of Asian Natural Products Research·Yu-Bo ZhangWei Meng
Dec 18, 2013·Molecular Medicine Reports·Ke HeGuoan Xiang

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