journal cover

Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology

ACS Medicinal Chemistry Letters

May 26, 2018

Sho KaideHideo Saji

Abstract

It is generally accepted that neurofibrillary tangles consisting of tau proteins are involved in the pathogenesis of Alzheimer's disease (AD). For selective detection of tau pathology, we synthesized and evaluated radioiodinated benzoimidazopyridine (BIP) derivatives with an alkylamino ...read more

Mentioned in this Paper

In Vivo
Pathogenic Aspects
Brain Diseases
Pathogenesis
Derivatives
Neurofibrillary Degeneration (Morphologic Abnormality)
GDF10 protein, human
Brain
Uptake
Alzheimer's Disease
1
9
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Traumatic Encephalopathy

Traumatic Encephalopathy is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Diffuse Neurofibrillary Tangles with Calcification

Diffuse Neurofibrillary Tangles with Calcification (DNTC) is a rare form of presenile dementia. Here is the latest research.

Tissue Engineering

Tissue engineering is an interdisciplinary field that aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Discover the latest research on tissue engineering here.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

Tauopathies

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. Discover the latest research on tauopathies here.

Tissue Therapy & Scaffolds

Tissue engineering aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Here is the latest research on biomaterial scaffolds that can be used for tissue therapy.

© 2020 Meta ULC. All rights reserved

Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology

ACS Medicinal Chemistry Letters

May 26, 2018

Sho KaideHideo Saji

PMID: 29795763

DOI: 10.1021/acsmedchemlett.8b00092

Abstract

It is generally accepted that neurofibrillary tangles consisting of tau proteins are involved in the pathogenesis of Alzheimer's disease (AD). For selective detection of tau pathology, we synthesized and evaluated radioiodinated benzoimidazopyridine (BIP) derivatives with an alkylamino ...read more

Mentioned in this Paper

In Vivo
Pathogenic Aspects
Brain Diseases
Pathogenesis
Derivatives
Neurofibrillary Degeneration (Morphologic Abnormality)
GDF10 protein, human
Brain
Uptake
Alzheimer's Disease
1
9

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/structure-activity-relationships-of/29795763