Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids

Bioorganic & Medicinal Chemistry Letters
James McNultyJaume Bastida

Abstract

The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series. Important elements of this novel pharmacophore were elucidated through structure-activity relationship (SAR) studies.

References

Jan 13, 2006·Chemical Reviews·José Marco-ContellesAntonio G García

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Citations

Aug 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan C CedrónAna Estévez-Braun
Dec 15, 2016·Expert Opinion on Therapeutic Patents·Stanton F McHardyMatthew C Valdez
Jul 1, 2014·The Journal of Organic Chemistry·Ping LanAnthony C Willis
May 7, 2013·Natural Product Reports·Zhong Jin
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eliška KohelováLucie Cahlíková
Jun 7, 2011·Drugs & Aging·Melanie-Jayne R Howes, Elaine Perry
Jan 1, 2013·Science China. Chemistry·ZhiFei CaoQuanSheng Zhou
Jan 1, 2012·Canadian Journal of Chemistry·Sergey VshyvenkoSiyaram Pandey
Jul 16, 2011·Bioorganic & Medicinal Chemistry Letters·Sergey VshyvenkoAlexander Kornienko
Aug 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mridul RoyJing Liu
Oct 19, 2010·Analytical Chemistry·Maria Rowena N MontonJohn D Brennan

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