Structure analysis using acoustically levitated droplets

Analytical and Bioanalytical Chemistry
Jork LeitererUlrich Panne

Abstract

Synchrotron diffraction with a micrometer-sized X-ray beam permits the efficient characterization of micrometer-sized samples, even in time-resolved experiments, which is important because often the amount of sample available is small and/or the sample is expensive. In this context, we will present acoustic levitation as a useful sample handling method for small solid and liquid samples, which are suspended in a gaseous environment (air) by means of a stationary ultrasonic field. A study of agglomeration and crystallization processes in situ was performed by continuously increasing the concentration of the samples by evaporating the solvent. Absorption and contamination processes on the sample container walls were suppressed strongly by this procedure, and parasitic scattering such as that observed when using glass capillaries was also absent. The samples investigated were either dissolved or dispersed in water droplets with diameters in the range of 1 micrometer to 2 millimeters. Initial results from time-resolved synchrotron small- and wide-angle X-ray scattering measurements of ascorbic acid, acetylsalicylic acid, apoferritin, and colloidal gold are presented.

References

Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Jan 5, 2002·Fresenius' Journal of Analytical Chemistry·P JacobD Klockow
Apr 23, 2003·Analytical Chemistry·Sabina SantessonStaffan Nilsson
Feb 6, 2004·Analytical and Bioanalytical Chemistry·Sabina Santesson, Staffan Nilsson
Jun 2, 2006·Analytical Chemistry·Dirk JanasekAndreas Manz
Jul 28, 2006·Nature·Dirk JanasekAndreas Manz
Nov 30, 2006·Angewandte Chemie·Andrew D BondGautam R Desiraju

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Citations

Sep 17, 2009·Analytical and Bioanalytical Chemistry·Ralf BienertAndreas F Thünemann
Nov 1, 2011·European Biophysics Journal : EBJ·Richard J K WeberStephen R Byrn
Feb 6, 2013·Journal of Pharmaceutical Sciences·Chris J BenmoreStephen R Byrn
Oct 17, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sönke RehderClaudia S Leopold
Jul 24, 2012·International Journal of Pharmaceutics·Amrit PaudelGuy Van den Mooter
Apr 12, 2016·Biochimica Et Biophysica Acta. General Subjects·J K R WeberS R Byrn
Apr 14, 2012·Biophysical Chemistry·Alexander Scheeline, Rachel L Behrens
May 7, 2016·Scientific Reports·Soichiro Tsujino, Takashi Tomizaki
Mar 25, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Zhen ChenXingguo Geng
Mar 28, 2017·Advances in Colloid and Interface Science·Duyang ZangXingguo Geng
Mar 11, 2020·Journal of Synchrotron Radiation·Pernille SønderbyPernille Harris
Jan 1, 2011·Analytical Methods : Advancing Methods and Applications·Jork LeitererSteffen M Weidner
Oct 13, 2017·Journal of Applied Crystallography·Brian R PauwAndreas F Thünemann
Jan 21, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Jörg PolteAndreas F Thünemann
Sep 23, 2009·Analytical Chemistry·Zakiah N PierreAlexander Scheeline
Mar 13, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Maria KlimakowFranziska Emmerling
Nov 15, 2012·The Journal of Physical Chemistry. B·Jonas SchenkMerwe Albrecht

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