Abstract
The physiological or pharmacological dissolution of thrombi is ultimately accomplished by the serine protease plasmin. Plasmin is derived from its precursor plasminogen in a reaction catalyzed by plasminogen activators (PAs) such as tissue-type plasminogen activator (tPA). In the middle of the last century, plasmin was investigated as a potential thrombolytic agent. However, technical obstacles led to the abandonment of this agent, and by the 1970s PAs had become the standard of care for pharmacological management of various thrombotic conditions. Talecris Biotherapeutics has developed a methodology to prepare the plasmin product (Human) TAL-05-00018 that is rendered inactive by low pH (pH 3.0-4.0) until it is delivered directly to the neutral environment of a thrombus by catheter-assisted administration. TAL-05-00018 undergoes a rigorous manufacturing process to ensure a final product free from unactivated plasminogen, streptokinase, enveloped and non-enveloped viruses and prion proteins; generating an extremely high-purity product with a shelf life of three years at ambient temperature. TAL-05-00018 has shown promise in in vitro and pre-clinical studies, and in early clinical trials, demonstrating a dose-dependant reduction i...Continue Reading
References
Oct 1, 1976·European Journal of Biochemistry·D Collen
Mar 15, 1978·European Journal of Biochemistry·B Wiman, D Collen
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·N B EgenF S Markland
Jan 1, 1980·European Journal of Biochemistry·P G LerchD Gillessen
Jan 1, 1996·Advances in Experimental Medicine and Biology·F S Markland
Jun 24, 1998·Biochemistry·E KomorowiczR Machovich
Mar 23, 2002·Haemostasis·C F Toombs
Nov 26, 2002·Blood·Daphne StewartVictor J Marder
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·V NovokhatnyT P Zimmerman
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·N NagaiD Collen
Jul 1, 1956·Circulation Research·N BACKJ W HARRISSON
Nov 1, 1956·Canadian Journal of Biochemistry and Physiology·E RONWIN
Jul 1, 1959·Circulation·K M MOSER
Aug 1, 1960·The American Journal of Cardiology·E E CLIFFTON
Aug 1, 1960·The American Journal of Cardiology·N D DAVISS H SCHWARTZ
Aug 1, 1960·The American Journal of Cardiology·R M HERNDONJ LANDERS
Jan 28, 2004·Investigative Ophthalmology & Visual Science·Arnd GandorferDavid Charteris
Apr 23, 2004·Trends in Pharmacological Sciences·Valery V NovokhatnyThomas P Zimmerman
Aug 18, 2005·Journal of Vascular and Interventional Radiology : JVIR·Kenneth OurielSteven R Deitcher
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephan MollSteven R Deitcher
Jan 17, 2007·Expert Opinion on Biological Therapy·Steven R DeitcherChristopher F Toombs
Apr 4, 2008·Journal of Thrombosis and Haemostasis : JTH·R D Shlansky-GoldbergV J Marder
Sep 4, 2008·Thrombosis and Haemostasis·Jennifer A HuntValery Novokhatny
Citations
Mar 31, 2011·Toxicon : Official Journal of the International Society on Toxinology·Cho Yeow Koh, R Manjunatha Kini
Sep 25, 2010·Biomaterials·Kristen M LorentzJeffrey A Hubbell
Oct 8, 2009·Clinical Therapeutics·Steve PakolaPeter Verhamme
Mar 25, 2014·Medicinal Research Reviews·Rami A Al-Horani, Umesh R Desai
Dec 1, 2009·Journal of Thrombosis and Haemostasis : JTH·V J Marder, V Novokhatny
Jun 10, 2015·BMC Biotechnology·Rongzeng LiuWei Mo
Jan 31, 2015·PloS One·Manuel CorreiaMaria Teresa Neves-Petersen
Nov 16, 2017·Microbial Cell Factories·Yanying XuDeqiang Wang
Apr 14, 2016·Biology Open·Anna GilbertBozena Czarkowska-Paczek
Dec 6, 2017·Toxins·Eladio F SanchezJohannes A Eble