Structure and activity relationships of tartrate-based TACE inhibitors

Bioorganic & Medicinal Chemistry Letters
Dansu LiCorey O Strickland

Abstract

The syntheses and structure-activity relationships of the tartrate-based TACE inhibitors are discussed. The optimization of both the prime and non-prime sites led to compounds with picomolar activity. Several analogs demonstrated good rat pharmacokinetics.

Citations

Oct 28, 1986·Biochimica Et Biophysica Acta·C L Reading, Y Takaue
Dec 13, 2012·Expert Opinion on Drug Discovery·Prashant R MurumkarMange Ram Yadav
Apr 5, 2011·Bioorganic & Medicinal Chemistry Letters·Chaoyang DaiM Arshad Siddiqui
Dec 22, 2009·Bioorganic & Medicinal Chemistry Letters·Kristin E RosnerCorey O Strickland
Dec 17, 2009·Bioorganic & Medicinal Chemistry Letters·Eric J GilbertDaniel J Lundell
Apr 14, 2020·Expert Opinion on Drug Discovery·Prashant R MurumkarMange Ram Yadav
Sep 8, 2018·Chemical Reviews·Allie Y ChenSeth M Cohen

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