Structure and Aggregation Mechanisms in Amyloids

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Zaida L Almeida, Rui M M Brito

Abstract

The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and deposition into insoluble plaques and intracellular inclusions is the hallmark of several misfolding diseases known as amyloidoses. Alzheimer's, Parkinson's and Huntington's diseases are some of the approximately 50 amyloid diseases described to date. The identification and characterization of the molecular species critical for amyloid formation and disease development have been the focus of intense scrutiny. Methods such as X-ray and electron diffraction, solid-state nuclear magnetic resonance spectroscopy (ssNMR) and cryo-electron microscopy (cryo-EM) have been extensively used and they have contributed to shed a new light onto the structure of amyloid, revealing a multiplicity of polymorphic structures that generally fit the cross-β amyloid motif. The development of rational therapeutic approaches against these debilitating and increasingly frequent misfolding diseases requires a thorough understanding of the molecular mechanisms underlying the amyloid cascade. Here, we review the current knowledge on amyloid fibril formation for several proteins and peptides from a kinetic and thermodynamic point of view, the structure of the molecular sp...Continue Reading

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Citations

Sep 2, 2020·International Journal of Molecular Sciences·Greta BianchiStefania Brocca
Jul 9, 2020·Computational and Structural Biotechnology Journal·Jaime SantosSalvador Ventura
Jan 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enric Mayans, Carlos Alemán
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana FrangolhoRui M M Brito
May 22, 2021·Biomaterials Science·Vijay KumarAshwani Kumar Thakur
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Danae Campos-MeloMichael J Strong
Jul 15, 2021·The Journal of Physical Chemistry. B·Hao WuTheodore W Randolph
Jul 13, 2021·The Journal of Physical Chemistry. B·Beata Szała-Mendyk, Andrzej Molski
Oct 6, 2021·Molecular Neurobiology·Céline VrancxPascal Kienlen-Campard
Nov 5, 2021·The Journal of Physical Chemistry. B·Debanjan BagchiAnjan Chakraborty

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Methods Mentioned

BETA
X-ray
protein folding

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