Structure and anticancer activity of native and modified polysaccharides from brown alga Dictyota dichotoma

Carbohydrate Polymers
Roza V UsoltsevaS P Ermakova

Abstract

The laminaran DdL and fucoidan DdF were obtained from the brown alga Dictyota dichotoma. DdF was a sulfated (28.9%) and acetylated heteropolysaccharide containing fucose, galactose, mannose and glucose (57.9, 20.4, 12.4 and 9.2mol%, respectively). DdL was a 1,3;1,6-β-d-glucan with the main chain built from 1,3-linked glucose residues and single glucose residue in branches at C6 (one branch on three glucose residues of the main chain). Sulfated (43.7%) laminaran DdLs was obtained from DdL by sulfation. It was determined that sulfates occur at C2, C4 and C6 of glucose residues. The anticancer effect of DdF, DdL, and DdLs (200μg/mL) was studied in vitro on colon cancer cells HCT-116, HT-29, and DLD-1. The effect of polysaccharides (40μg/mL) on colony formation of DLD-1 cancer cells after irradiation (4Gy) was investigated first. All polysaccharides showed a synergistic effect with X-ray irradiation against cancer cells, decreasing the amount and size of cancer cells colonies.

Citations

Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xu BaiAiguo Ji
Jul 11, 2018·Marine Drugs·Ariana A Vasconcelos, Vitor H Pomin
Dec 3, 2020·Antioxidants·Marília Medeiros Fernandes-NegreirosHugo Alexandre Oliveira Rocha
Dec 17, 2020·Frontiers in Plant Science·Nora M A Ponce, Carlos A Stortz
Jul 13, 2020·International Journal of Biological Macromolecules·Weihua JinWeihong Zhong
Jul 15, 2020·International Journal of Biological Macromolecules·Roza V UsoltsevaSvetlana P Ermakova
May 24, 2021·International Journal of Biological Macromolecules·Roza V UsoltsevaSvetlana P Ermakova
Jul 27, 2021·Journal of Polymers and the Environment·Sonal NigamSurbhi Sinha

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