Structure and bioactivity of neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum.

The Journal of Biological Chemistry
Judith E HumphriesTim A Day

Abstract

The blood flukes Schistosoma mansoni and Schistosoma japonicum inflict immense suffering as agents of human schistosomiasis. Previous investigations have found the nervous systems of these worms contain abundant immunoreactivity to antisera targeting invertebrate neuropeptide Fs (NPFs) as well as structurally similar neuropeptides of the mammalian neuropeptide Y (NPY) family. Here, cDNAs encoding NPF in these worms were identified, and the mature neuropeptides from the two species differed by only a single amino acid. Both neuropeptides feature the characteristics common among NPFs; they are 36 amino acids long with a carboxyl-terminal Gly-Arg-X-Arg-Phe-amide and Tyr residues at positions 10 and 17 from the carboxyl terminus. Synthetic S. mansoni NPF potently inhibits the forskolin-stimulated accumulation of cAMP in worm homogenates, with significant effects at 10(-11) m. This is the first demonstration of an endogenous inhibition of cAMP by an NPF, and because this is the predominant pathway associated with vertebrate NPY family peptides, it demonstrates a conservation of downstream signaling pathways used by NPFs and NPY peptides.

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Citations

Dec 21, 2007·Cell and Tissue Research·Natalia D KreshchenkoMargaretha K S Gustafsson
May 21, 2011·Cell and Tissue Research·Andrew E Christie
Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
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Jul 17, 2009·Nature·Matthew BerrimanNajib M El-Sayed
Mar 25, 2011·The Journal of Experimental Biology·Andrew E ChristiePetra H Lenz
Oct 23, 2010·PLoS Biology·James J CollinsPhillip A Newmark
Jan 19, 2016·International Journal for Parasitology·Natasha L HirstAnthony J Walker
Apr 14, 2009·International Journal for Parasitology·Paul McVeighAaron G Maule
Mar 17, 2007·International Journal for Parasitology·Hanan H OmarTim A Day
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Paul McVeighAaron G Maule
May 11, 2011·International Journal for Parasitology·Paul McVeighAaron G Maule
May 22, 2010·Molecular and Biochemical Parasitology·Louise E AtkinsonAaron G Maule
Nov 11, 2009·International Journal for Parasitology·Lisa PiersonAaron G Maule
Oct 24, 2018·Pest Management Science·Shuqian TanWangpeng Shi
Mar 7, 2019·Frontiers in Endocrinology·Melissa FaddaLiliane Schoofs

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