PMID: 2114180Jun 21, 1990Paper

Structure and developmental expression of chicken nucleolin and NO38: coordinate expression of two abundant non-ribosomal nucleolar proteins

Biochimica Et Biophysica Acta
G MaridorE A Nigg

Abstract

We report the complete primary structures of two major chicken non-ribosomal nucleolar proteins known as nucleolin/C23 and NO38/B23, respectively. By comparison with homologous proteins from other species, this sequence information contributes to the identification of evolutionarily conserved motifs that may be relevant to the function and subcellular distribution of the two proteins. Using cDNA probes and monoclonal antibodies, we have also studied the expression of nucleolin and NO38 in the course of chicken embryogenesis. In all tissues examined, Northern analyses revealed single hybridization signals for nucleolin (at 3.0 kb) and NO38 (at 1.6 kb), and no evidence was obtained for multiple protein products. In total embryos between days 3 and 11 after egg laying, nucleolin and NO38 mRNA and protein levels decreased in parallel (2-5-fold), suggesting transcriptional down-regulation of expression. Coordinate expression of nucleolin and NO38 was observed also when examining individual tissues at various stages of development. Interestingly, however, there was no consistent correlation between relative mRNA and protein levels. In particular, several adult tissues contained exceedingly low levels of either nucleolin or NO38, desp...Continue Reading

References

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Citations

Oct 1, 1995·Protein Science : a Publication of the Protein Society·J S EvansW A Goddard
Jan 12, 1995·Molecular and Cellular Biochemistry·B Klocke, W Knöchel
Oct 12, 2005·Histochemistry and Cell Biology·Fernando González-Camacho, Francisco Javier Medina
Jan 1, 1993·Pharmacology & Therapeutics·O G Issinger
Jun 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S SiemerO G Issinger
Jan 1, 1997·Molecular Biology of the Cell·K E McGrathC D Allis
Aug 1, 1996·Nucleic Acids Research·A InoueS Morisawa
Jun 25, 1993·Biochimica Et Biophysica Acta·G M Lamm, A I Lamond
Jul 1, 1991·Genes & Development·A GilM A Garcia-Blanco

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