PMID: 2117557Aug 20, 1990Paper

Structure and developmental expression of the D alpha 2 gene encoding a novel nicotinic acetylcholine receptor protein of Drosophila melanogaster

FEBS Letters
P E JonasE D Gundelfinger

Abstract

Nicotinic acetylcholine receptors (nAChRs) represent a heterogeneous group of excitatory neurotransmitter receptors in the insect brain. We have characterized the D alpha 2 gene of Drosophila melanogaster, a new member of the nAChR gene family. The protein coding region is interrupted by six introns. The positions of three of these introns are shared with all other nAChR genes. The deduced D alpha 2 protein shows the structural features of ligand-binding nAChR alpha-subunits. Cytogenetically, the D alpha 2 gene maps at position 96A of the 3rd chromosome, close to the ALS gene which also encodes an alpha-like nAChR subunit. D alpha 2 transcripts are predominantly expressed in late embryos and in fly heads.

References

Feb 11, 1990·Nucleic Acids Research·R Baumann, M Smith
Jul 15, 1986·European Journal of Biochemistry·F Hucho
May 25, 1989·Nature·M Ashburner, D Gubb
Mar 1, 1989·Journal of Neurochemistry·K E Isenberg, G E Meyer
Jan 1, 1987·Molecular Neurobiology·J LindstromP Whiting
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P NefM Ballivet

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Citations

Jun 1, 1992·Trends in Neurosciences·E D Gundelfinger
Nov 17, 1992·Biochimica Et Biophysica Acta·E D Gundelfinger, N Hess
Sep 5, 2002·Annual Review of Entomology·Motohiro Tomizawa, John E Casida
Nov 7, 2001·Pest Management Science·M Tomizawa, J E Casida

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