Structure and dissolution of L-leucine-coated salbutamol sulphate aerosol particles.

AAPS PharmSciTech
Janne RaulaEsko I Kauppinen

Abstract

L-Leucine formed different crystalline coatings on salbutamol sulphate aerosol particles depending on the saturation conditions of L-leucine. The work emphasizes a careful characterization of powders where structural compartments such as crystal size and particle coating may affect the performance of drug when administered. The sublimation of L-leucine from the aerosol particles took place 90°C lower temperature than the bulk L-leucine which was attributed to result from the sublimation of L-leucine from nano-sized crystalline domains. The dissolution slowed down and initial dissolution rate decreased with increasing L-leucine content. Decreasing crystalline domains to nano-scale improve heat and mass transfer which was observed as the lowered decomposition temperature of the drug salbutamol sulphate and the sublimation temperature of surface material L-leucine as well as the altered dissolution characteristics of the drug. The structure of the coated drug particles was studied by means of thermal analysis techniques (DSC and TG), and the dissolution of salbutamol sulphate was studied as an on-line measurement in a diffusion cell.

References

Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
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Mar 7, 2002·Journal of the American Chemical Society·Kimberly DickDan Meisel
Oct 24, 2007·Pharmaceutical Research·Janne RaulaEsko I Kauppinen
Apr 15, 2008·International Journal of Pharmaceutics·Anna LähdeEsko I Kauppinen
Sep 16, 2008·International Journal of Pharmaceutics·Janne RaulaEsko I Kauppinen
Apr 5, 2011·International Journal of Pharmaceutics·Peng LiuLeena Peltonen

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Citations

Jan 26, 2016·Molecular Pharmaceutics·T ParumasivamHak-Kim Chan
Mar 11, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Zsófia Edit PápayIstván Antal
Nov 23, 2016·AAPS PharmSciTech·Bhavani Prasad VinjamuriWilliam C Stagner
Aug 5, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Siti Nani NurbaetiJean-Christophe Olivier

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