PMID: 6976315Dec 1, 1981Paper

Structure and expression of glycoproteins controlled by the Qa-1a allele

Immunogenetics
E Rothenberg, D Triglia

Abstract

The alloantigen controlled by the Qa-1a allele is a glycoprotein that exists in two forms. The first, an intracellular molecule of apparent Mr 44 000 daltons, appears to be a kinetic precursor of the second, a cell-surface molecule with an apparent size of 47 000 daltons. The intracellular form of Qa-1 is distinct from that of the TL glycoprotein in two ways: (1) its polypeptide backbone is approximately 5000 daltons shorter, and (2) it possesses three sites of high-mannose carbohydrate attachment, while TL has only one. In the cell-surface form of Qa-1, all three carbohydrate chains are processed to structures that resist endoglycosidase H digestion, presumably complex-type oligosaccharides. Concomitant with these late carbohydrate-processing steps is the formation of stable complexes between Qa-1 and beta 2-microglobulin. The timing of this association provides a further contrast between Qa-1 and TL, which is associated with beta 2-microglobulin shortly after its synthesis. The Qa-1 glycoproteins have been identified genetically by their synthesis in B6-TL+ (Qa-1a/Tlaa) splenocytes but not in splenocytes of congenic B6.K1 and B6.K2 (Qa-1b/Tlab) mice, and by their absence from the products of BALB/c (Qa-1b/Tlac) splenocytes. T...Continue Reading

References

Feb 27, 1975·Nature·L OstbergP A Peterson
Jul 1, 1976·The Journal of Experimental Medicine·E S VitettaJ W Uhr
Feb 1, 1977·The Journal of Experimental Medicine·T H HansenD H Sachs
Oct 1, 1979·The Journal of Experimental Medicine·E Rothenberg, E A Boyse
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L J Wysocki, V L Sato
Aug 15, 1975·European Journal of Biochemistry·R A Laskey, A D Mills
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Apr 8, 1974·Biochimica Et Biophysica Acta·S G Nathenson, S E Cullen
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Oct 1, 1980·The Journal of Experimental Medicine·A K BhanS F Schlossman
Jul 1, 1980·Immunogenetics·J MichaelsonE A Boyse
Jan 1, 1980·Immunogenetics·T H Stanton, L Hood
Jan 1, 1980·Journal of Supramolecular Structure·E Rothenberg, D Triglia

❮ Previous
Next ❯

Citations

Jan 1, 1987·Immunogenetics·D N MisraT J Gill
Jan 1, 1987·Immunologic Research·Y T ChenL J Old
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F Imani, M J Soloski
Jan 1, 1983·The Journal of Experimental Medicine·E Rothenberg, D Triglia
Dec 1, 1990·The Journal of Experimental Medicine·P R Wolf, R G Cook
Oct 28, 1997·European Journal of Immunology·L A CotterillP J Dyson
Oct 1, 1984·Journal of Immunogenetics·R A HarrisI F McKenzie
Oct 1, 1995·Immunological Reviews·M J SoloskiJ Forman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.