PMID: 3769926Oct 15, 1986Paper

Structure and expression of the chicken epidermal growth factor receptor gene locus

European Journal of Biochemistry
B OlofssonA Therwath

Abstract

Similarity between the carboxyl-terminal portion of the human epidermal growth factor (EGF) receptor and the deduced protein sequence of the chicken-derived oncogene v-erbB, of avian erythroblastosis virus strain H, has suggested that the chicken cellular erbB locus, c-erbB, might be part of a longer EGF-receptor gene in the chicken, whose entire coding capacity remained to be defined. The c-erbB locus spans more than 20 X 10(3) base pairs (20 kbp) of DNA and contains at least 1.8 kbp homologous to the v-erbB oncogene. We show here that human EGF receptor cDNA and chicken genomic DNA share homology not only within the c-erbB locus but also within a 25.1-kbp DNA region situated 5' to this locus. The 3' region of the EGF receptor overlaps, in sequence homology, the c-erbB locus. The EGF receptor/c-erbB locus in chicken generates six related but distinctly different mRNAs of sizes 12, 9, 5, 3.6, 3.2 and 2.6 kb. The transcripts of 12, 9, and 3.6 kb contain sequences coding for both the extracellular EGF-binding domain of the receptor and the intracellular tyrosine kinase domain. The 12-kb and 9-kb transcripts, which have already been shown to contain the sequences coding for the v-erbB, were found to possess, in addition, sequences...Continue Reading

References

Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A RainesH J Kung
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M KasugaC R Kahn
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W C Barker, M O Dayhoff
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
May 1, 1984·Cell·C H Heldin, B Westermark

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Citations

Mar 22, 2003·Experimental Cell Research·Julie L BoernerNita J Maihle
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N J MaihleH J Kung
Feb 1, 1989·Biochimica Et Biophysica Acta·N J Maihle, H J Kung
Feb 15, 2003·Developmental Cell·Radhika AtitLee Niswander

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