Structure and function in the conceptual development of mammalian neuroendocrinology between 1920 and 1965

Brain Research Reviews
Alan G Watts

Abstract

With the growing realization in the 1930s that the brain played a crucial role in regulating the secretions of the pituitary gland, neuroendocrinology as we now know it developed from two rather separate directions. One approach relied heavily on morphological techniques to define neurosecretion; a novel, but for many years flawed model that was originally developed to explain the presence of gland-like cells in the diencephalon. During its first 20 years neurosecretion, as a concept, made no significant contribution to our understanding of how the pituitary was controlled. Then, following the identification by Sanford Palay and Wolfgang Bargmann of a continuous neurosecretory pathway from the hypothalamus to the neural lobe, neurosecretion became incorporated into a more broadly based concept of pituitary function, particularly regarding the neural lobe. The second approach integrated structural and functional methods to investigate neural regulation of the pituitary. This work eventually explained how the pituitary was controlled by the brain. It led directly to our understanding of the control of vasopressin and oxytocin release by neuroendocrine terminals in the neural lobe, the neurohumoral control of the pars distalis, an...Continue Reading

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