PMID: 15227728Jul 1, 2004Paper

Structure and function of a minimal receptor activation domain of parathyroid hormone

Yonsei Medical Journal
Eun Jin LeeSung Kil Lim

Abstract

The structure and function of short-length amino terminal PTH analogues were studied. The substitution of Leu(7) with Phe in [Ala(3,10)Leu(7)Arg(11)]rPTH(1-11)NH(2) analogue peptides did not show any reduction in cAMP formation. Replacement of the 1st, 7th and 8th residues revealed different activities, depending upon the residue type. The substitution of Ala1 by Ser in [Ala(3,10)Leu(7)Arg(11)]rPTH(1-11)NH(2) caused nearly a complete loss of cAMP formation. Meanwhile, NMR analysis of [(Ala(1)/ Ser(1))Ala(3,10)(Leu(7)/Phe(7))Arg(11)]rPTH(1-11)NH(2) revealed an alpha-helical backbone structure with a flexible conformation at the carboxyl-terminus. The overall results suggest that 11-residue short oligopeptide analogues of PTH tend to form an alpha-helical structure and the different activities of those analogues could be associated with residue specificity rather than the secondary conformational structure.

Citations

Apr 19, 2019·Future Medicinal Chemistry·Yanwen ZhongKejiang Lin
Feb 3, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·A BarazzaM Chorev

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