Structure and function of animal cryptochromes

Cold Spring Harbor Symposia on Quantitative Biology
Nuri OzturkAziz Sancar

Abstract

Cryptochrome (CRY) is a photolyase-like flavoprotein with no DNA-repair activity but with known or presumed blue-light receptor function. Animal CRYs have DNA-binding and autokinase activities, and their flavin cofactor is reduced by photoinduced electron transfer. In Drosophila, CRY is a major circadian photoreceptor, and in mammals, the two CRY proteins are core components of the molecular clock and potential circadian photoreceptors. In mammals, CRYs participate in cell cycle regulation and the cellular response to DNA damage by controlling the expression of some cell cycle genes and by directly interacting with checkpoint proteins.

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L JohnsonA Sancar
Jun 30, 1995·Science·H W ParkJ Deisenhofer
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S T KimG T Babcock
Jan 1, 1993·Annual Review of Physiology·C S Pittendrigh
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y F LiA Sancar
Mar 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A J Millar, S A Kay
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·C LinA R Cashmore
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y Miyamoto, A Sancar
Jul 27, 1999·Science·M F CerianiS A Kay
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·M H VitaternaA Sancar
Oct 16, 1999·Brain Research. Molecular Brain Research·Y Miyamoto, A Sancar
Feb 2, 2000·Biophysical Journal·T RitzK Schulten
Mar 31, 2000·Progress in Cell Cycle Research·G A Bjarnason, R Jordan
Jun 17, 2000·Photochemistry and Photobiology·S S Nikaido, C H Johnson
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·C P SelbyA Sancar
Jul 10, 2001·The Journal of Biological Chemistry·T E SwartzR A Bogomolni
Sep 5, 2001·Nature Reviews. Genetics·M W Young, S A Kay
Jun 18, 2002·Plant Physiology·Margaret AhmadDanielle Lardemer
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Mar 12, 2003·Biochemistry·Sezgin Ozgur, Aziz Sancar
Jul 9, 2003·European Journal of Biochemistry·Jean-Pierre BoulyMargaret Ahmad
Aug 2, 2003·Nature·Tomonao MatsushitaAkira Nagatani
Aug 23, 2003·Science·Takuya MatsuoHitoshi Okamura
Sep 13, 2003·Science·Shannon M HarperKevin H Gardner

❮ Previous
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Citations

Mar 17, 2009·Journal of Assisted Reproduction and Genetics·Ann A KiesslingDimitris Loutradis
Dec 20, 2011·Biochemistry·Christopher P Selby, Aziz Sancar
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nuri OzturkAziz Sancar
Oct 26, 2012·The Journal of Biological Chemistry·Ryuji WatariToshiyuki Okano
Nov 15, 2011·The Journal of Biological Chemistry·Timothy SextonRussell N Van Gelder
Aug 7, 2008·The Journal of Biological Chemistry·Aziz Sancar
Feb 21, 2009·Molecular Biology and Evolution·José Ignacio Lucas-Lledó, Michael Lynch
Nov 13, 2009·Journal of the Royal Society, Interface·Miriam Liedvogel, Henrik Mouritsen
Aug 24, 2013·Journal of the Royal Society, Interface·Christine NießnerRoswitha Wiltschko
Dec 12, 2012·Journal of Biological Rhythms·Jennifer A EvansDavid K Welsh
Mar 20, 2009·PLoS Biology·Michael Rosbash
Mar 11, 2011·PloS One·Benjamin D WegerThomas Dickmeis
Jun 7, 2014·Annual Review of Biochemistry·Brian R Crane, Michael W Young
Apr 9, 2014·BMC Gastroenterology·Ming-Luen HuMing-Yu Yang
Jul 6, 2014·Annual Review of Microbiology·Margaret J McFall-Ngai
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ethan D Buhr, Russell N Van Gelder
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anand T VaidyaBrian R Crane
Jan 15, 2015·Biosensors·Roswitha Wiltschko, Wolfgang Wiltschko
Dec 31, 2015·Proceedings of the National Academy of Sciences of the United States of America·James E Cleaver
Dec 1, 2009·Experimental Parasitology·M Carolaing GabaldónLuisana Avilan
Jun 4, 2011·The FEBS Journal·Peter MacherouxSteven E Ealick
Jul 31, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ana del PozoFrancisco Javier Sánchez-Vázquez
Jun 5, 2015·Frontiers in Molecular Biosciences·Gabriel Thieulin-PardoBrigitte Gontero
Jul 14, 2010·Fungal Genetics and Biology : FG & B·Deborah Bell-Pedersen
Feb 27, 2014·Marine Genomics·Paola OliveriAngela Falciatore
Apr 2, 2015·Annual Review of Physical Chemistry·Dongping Zhong
Jun 9, 2016·Psychiatry Research·Leena KovanenTimo Partonen
Dec 20, 2016·Photochemistry and Photobiology·Meng ZhangDongping Zhong
Nov 20, 2016·Photochemistry and Photobiology·Nuri Ozturk
Dec 20, 2017·Scientific Reports·Alberto BiscontinRodolfo Costa
Oct 19, 2017·Cold Spring Harbor Perspectives in Biology·Koji L Ode, Hiroki R Ueda
Oct 31, 2018·Scientific Reports·Tuba KorkmazNuri Ozturk
May 24, 2017·Annual Review of Vision Science·Russell N Van Gelder, Ethan D Buhr

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