PMID: 26806410Jan 26, 2016Paper

Structure and Function of CW Domain Containing Proteins

Current Protein & Peptide Science
Yanli LiuChao Qi

Abstract

The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensively expressed in vertebrates, vertebrate-infecting parasites and higher plants, where they are often involved in chromatin remodeling, methylation recognition, epigenetic regulation and early embryonic development. Since the first CW domain structure was determined 5 years ago, structures of five CW domains have been solved so far. In this review, we will discuss these recent advances in understanding the identification, definition, structure, and functions of the CW domain containing proteins.

Citations

Jun 6, 2017·Nature Genetics·Iva A TchasovnikarovaPaul J Lehner
Mar 5, 2016·The Journal of Biological Chemistry·Yanli LiuJinrong Min

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