PMID: 8584887Jul 1, 1995Paper

Structure and function of FMR

Sheng li ke xue jin zhan [Progress in physiology]
T HuangG Y Wu

Abstract

The widespread basal expression of fragile X gene (FMR1) suggests that it is a house keeping gene, essential to the survival and function of the cells, but unrelated to proliferation and phenogenesis. The spatial temporal specific expression of FMR1 further suggests that it is an important development-regulating gene, essential to development, particularly to the development of CNS and reproductive system, and may play an important role in cell migration and differantiation. It may also be a posttranscription regulator, by binding to mRNA, regulates the posttranscription processing, transportation, translation and localization of mRNAs. The diversity of pathogenesis of Fra(X) individuals may be caused by the variation of the downstream genes regulated by FMR1.

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