Structure and Function of Hepatobiliary ATP Binding Cassette Transporters.

Chemical Reviews
Tim KrollLutz Schmitt

Abstract

The liver is beyond any doubt the most important metabolic organ of the human body. This function requires an intensive crosstalk within liver cellular structures, but also with other organs. Membrane transport proteins are therefore of upmost importance as they represent the sensors and mediators that shuttle signals from outside to the inside of liver cells and/or vice versa. In this review, we summarize the known literature of liver transport proteins with a clear emphasis on functional and structural information on ATP binding cassette (ABC) transporters, which are expressed in the human liver. These primary active membrane transporters form one of the largest families of membrane proteins. In the liver, they play an essential role in for example bile formation or xenobiotic export. Our review provides a state of the art and comprehensive summary of the current knowledge of hepatobiliary ABC transporters. Clearly, our knowledge has improved with a breath-taking speed over the last few years and will expand further. Thus, this review will provide the status quo and will lay the foundation for new and exciting avenues in liver membrane transporter research.

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Citations

Mar 7, 2021·International Journal of Molecular Sciences·Amel Ben SaadThomas Falguières
Mar 3, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Amel Ben SaadThomas Falguières
May 29, 2021·Biological Chemistry·Christoph G W GertzenLutz Schmitt
Jun 10, 2021·Structure·Martin PrescherLutz Schmitt
May 23, 2021·Journal of Lipid Research·Tim KrollLutz Schmitt
Jul 3, 2021·International Journal of Molecular Sciences·Amel Ben SaadThomas Falguières

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