Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes

FEMS Microbiology Letters
Veeraraghavan UshaGurdyal S Besra

Abstract

Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.

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Citations

Oct 6, 2015·International Journal of Molecular Sciences·Jianzhou MengZhongyang Lu
Dec 18, 2015·Physical Chemistry Chemical Physics : PCCP·Debodyuti Dutta, Sabyashachi Mishra
Oct 27, 2016·The Journal of Physical Chemistry. B·Debodyuti Dutta, Sabyashachi Mishra
Jun 12, 2019·FEMS Microbiology Reviews·Arundhati MaitraSanjib Bhakta
Sep 21, 2018·Glycoconjugate Journal·Tripti RaghavendraRaju Mukherjee
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fengyu GuoWeijun Chen

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