PMID: 22339732DOI: 10.1111/j.1574-6968.2012.02527.xFeb 22, 2012Paper
Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes
FEMS Microbiology Letters
Veeraraghavan UshaGurdyal S Besra
Abstract
Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.
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