PMID: 2478831Jan 1, 1989Paper

Structure and function of peripheral vascular smooth muscle in hypertension.

Journal of Cardiovascular Pharmacology
Michael J Mulvany

Abstract

This paper reviews previous work from our laboratory concerning the role of resistance vessel abnormalities in the pathogenesis of high blood pressure both in humans and in the spontaneously hypertensive rat. In both humans and rat, a number of resistance vessel characteristics differ between those from hypertensive individuals and those from normotensive controls, including vascular structure (expressed as media:lumen ratio in rat vessels and media cross-sectional area in human vessels) and the sensitivity of the norepinephrine concentration-response curve to cocaine (expressed as a "cocaine shift," and possibly being a marker for amount of sympathetic innervation). Moreover, in F2-generation hypertensive/normotensive rats at least, there was a weak (p = 0.06) correlation between vascular structure and cocaine shift. These results suggest that vascular structure is altered in hypertension, and we have been interested in whether treatment causes regression of these abnormalities. In essential hypertensive patients who had been treated for about 1 year, or in rats that were treated from age 4 to 24 weeks, neither vascular structure nor "cocaine shift" was fully normalized. It is suggested that this failure to obtain full regress...Continue Reading

Citations

May 1, 1994·Clinical and Experimental Hypertension : CHE·M D Ashen, J M Hamlyn
Jan 18, 2006·Journal of Biomedical Optics·Andreea Trache, Gerald A Meininger

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