Structure and function of the molecular chaperone Trigger Factor

Biochimica Et Biophysica Acta
Anja HoffmannGünter Kramer

Abstract

Newly synthesized proteins often require the assistance of molecular chaperones to efficiently fold into functional three-dimensional structures. At first, ribosome-associated chaperones guide the initial folding steps and protect growing polypeptide chains from misfolding and aggregation. After that folding into the native structure may occur spontaneously or require support by additional chaperones which do not bind to the ribosome such as DnaK and GroEL. Here we review the current knowledge on the best-characterized ribosome-associated chaperone at present, the Escherichia coli Trigger Factor. We describe recent progress on structural and dynamic aspects of Trigger Factor's interactions with the ribosome and substrates and discuss how these interactions affect co-translational protein folding. In addition, we discuss the newly proposed ribosome-independent function of Trigger Factor as assembly factor of multi-subunit protein complexes. Finally, we cover the functional cooperation between Trigger Factor, DnaK and GroEL in folding of cytosolic proteins and the interplay between Trigger Factor and other ribosome-associated factors acting in enzymatic processing and translocation of nascent polypeptide chains.

References

Nov 5, 1992·Journal of Molecular Biology·T CrombieA J Brown
Jan 1, 1987·Journal of Bacteriology·K H Paek, G C Walker
Jul 5, 1987·Nature·J Ellis
Jul 20, 1973·Science·C B Anfinsen
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H Alix, M F Guérin
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·T HesterkampB Bukau
Sep 23, 1997·Journal of Molecular Biology·T ZarntG Fischer
Jun 6, 1998·Journal of Molecular Biology·T TsalkovaB Hardesty
Jan 26, 2000·Nature·W A HouryF U Hartl
Apr 5, 2000·The Journal of Biological Chemistry·V A KolbA S Spirin
Jun 29, 2000·Trends in Biochemical Sciences·A R DinnerM Karplus
Jul 13, 2000·Protein Science : a Publication of the Protein Society·G C HuangG Fischer
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·H C Lee, H D Bernstein
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·H PatzeltE Deuerling
Dec 18, 2001·Journal of Molecular Biology·R MaierF X Schmid
Aug 2, 2002·Molecular Cell·Jennifer A MakiGloria M Culver
Sep 3, 2002·The Journal of Biological Chemistry·Hin C Lee, Harris D Bernstein
Sep 13, 2002·Nature·Günter KramerBernd Bukau
Nov 28, 2002·Biological Chemistry·Holger PatzeltElke Deuerling
Dec 12, 2002·Cellular and Molecular Life Sciences : CMLS·M Haslbeck

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Citations

May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tatsuya NiwaHideki Taguchi
May 26, 2010·The Journal of Biological Chemistry·Sebastian Falk, Irmgard Sinning
Sep 27, 2013·PLoS Genetics·Anita Krisko, Miroslav Radman
Apr 9, 2013·PloS One·Kushagra SinghalPeter G Bolhuis
May 15, 2013·PloS One·Karthik Krishnan, Margaret J Duncan
Feb 12, 2014·Biochemistry. Biokhimii︠a︡·O E MelkinaG B Zavilgelsky
Jun 19, 2014·Nature Communications·Thomas BornemannWolfgang Wintermeyer
Mar 5, 2011·Annual Review of Biochemistry·Christine L HaganDaniel Kahne
Sep 7, 2014·Biotechnology Advances·Katerina ZelenaRalf G Berger
Apr 17, 2012·Trends in Biochemical Sciences·Steffen Preissler, Elke Deuerling
Dec 1, 2015·Nature Structural & Molecular Biology·Frederick StullJames C A Bardwell
Jan 26, 2011·Journal of Molecular Biology·Erik Martinez-Hackert, Wayne A Hendrickson
Nov 12, 2015·Biochimica Et Biophysica Acta·Adina BreimanCarmela Giglione
Mar 27, 2015·Biophysical Journal·Björn M BurmannSebastian Hiller
Apr 3, 2012·Molecular Microbiology·Mohit Kumar, Victor Sourjik
Jun 3, 2011·Protein Science : a Publication of the Protein Society·Brent L Nannenga, François Baneyx
May 4, 2011·Biotechnology Journal·Sujata Jha, Anton A Komar
Feb 14, 2015·Journal of Molecular Biology·Philipp A M Schmidpeter, Franz X Schmid
Mar 30, 2016·Applied Microbiology and Biotechnology·Pornpimol MahamadWatanalai Panbangred
Apr 4, 2016·Journal of Molecular Biology·Marina V Rodnina, Wolfgang Wintermeyer
May 31, 2011·Microbiology·Julien MaillardChristof Holliger
Nov 13, 2014·Environmental Microbiology·Amandine Godin-RoullingGeorges Feller
Dec 23, 2014·Biochimica Et Biophysica Acta·Can M Ünal, Michael Steinert
Dec 12, 2012·The Biochemical Journal·Katerina E ChatziAnastassios Economou
Aug 19, 2015·Frontiers in Molecular Biosciences·Ohad Suss, Dana Reichmann
May 9, 2014·Science·Martin Gamerdinger, Elke Deuerling
May 9, 2014·Science·Tomohide SaioCharalampos G Kalodimos
Jan 24, 2012·Bioresource Technology·Kateryna ZelenaRalf G Berger
May 3, 2014·Anaerobe·Anne-Cécile Hochart-BehraJosette Behra-Miellet
Mar 17, 2015·European Journal of Pharmacology·Saeed Sadigh-EteghadShirin Babri
Nov 26, 2013·Biochimica Et Biophysica Acta·Marie-Pierre Castanié-CornetPierre Genevaux
Dec 30, 2014·Frontiers in Microbiology·Ambre SalaPierre Genevaux
Jul 28, 2016·Frontiers in Molecular Neuroscience·Daniel A Nissley, Edward P O'Brien
May 6, 2016·Annual Review of Biophysics·Boon Chong GohKlaus Schulten

❮ Previous
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