Structure and function of the somatosensory system: a neurotoxicological perspective

Environmental Health Perspectives
Joseph C ArezzoP S Spencer

Abstract

The somatosensory system comprises those elements of the peripheral nervous system (PNS) and the central nervous system (CNS) subserving the modalities of touch, vibration, temperature, pain and kinesthesia. Specific modalities can be associated with unique peripheral receptors, peripheral axons of stereotyped diameter and specific central projection pathways. Several features of the somatosensory system render regions of it vulnerable to a wide variety of toxicants. The present report highlights these features and , furthermore, suggests that analysis of these regions is invaluable in studying the three most common varieties of toxic neuropathy: toxic distal axonopathy, toxic myelinopathy and toxic sensory neuronopathy.

References

Feb 1, 1979·Electroencephalography and Clinical Neurophysiology·J ArezzoH G Vaughan
Oct 1, 1978·Environmental Health Perspectives·P S Spencer, H H Schaumburg
Apr 1, 1974·Journal of Neuropathology and Experimental Neurology·H H SchaumburgP S Spencer
Jun 1, 1973·Journal of Neurocytology·P S Spencer, H H Schaumburg
Jan 1, 1981·Electroencephalography and Clinical Neurophysiology·Joseph C ArezzoA D Legatt
Apr 1, 1980·Annals of Neurology·A B StermanA K Asbury

Citations

Sep 1, 1993·Neurotoxicology and Teratology·J L MattssonP J Spencer
May 10, 2008·Toxicologic Pathology·John C PettersenAllan R Buchholz
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·H H SchaumburgJoseph C Arezzo
Sep 1, 1984·Pain·Mark E Owens, Ellen H Todt
Aug 28, 2019·Neuroscience Letters·Deva Sharma, Amanda M Brandow

Related Concepts

Metazoa
Nervous System Disorder
Neural Pathways
Alpha-Neurotoxins
Perineurium
Sensory Receptor Cells
Esthesia
Somatosensory Cortex

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