Structure and function of the somatosensory system: a neurotoxicological perspective

Environmental Health Perspectives
Joseph C ArezzoP S Spencer


The somatosensory system comprises those elements of the peripheral nervous system (PNS) and the central nervous system (CNS) subserving the modalities of touch, vibration, temperature, pain and kinesthesia. Specific modalities can be associated with unique peripheral receptors, peripheral axons of stereotyped diameter and specific central projection pathways. Several features of the somatosensory system render regions of it vulnerable to a wide variety of toxicants. The present report highlights these features and , furthermore, suggests that analysis of these regions is invaluable in studying the three most common varieties of toxic neuropathy: toxic distal axonopathy, toxic myelinopathy and toxic sensory neuronopathy.


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Oct 1, 1978·Environmental Health Perspectives·P S Spencer, H H Schaumburg
Apr 1, 1974·Journal of Neuropathology and Experimental Neurology·H H SchaumburgP S Spencer
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Sep 1, 1993·Neurotoxicology and Teratology·J L MattssonP J Spencer
May 10, 2008·Toxicologic Pathology·John C PettersenAllan R Buchholz
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·H H SchaumburgJoseph C Arezzo
Sep 1, 1984·Pain·Mark E Owens, Ellen H Todt
Aug 28, 2019·Neuroscience Letters·Deva Sharma, Amanda M Brandow

Related Concepts

Nervous System Disorder
Neural Pathways
Sensory Receptor Cells
Somatosensory Cortex

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