Structure and function of WD40 domain proteins

Protein & Cell
Chao Xu, Jinrong Min

Abstract

The WD40 domain exhibits a β-propeller architecture, often comprising seven blades. The WD40 domain is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes. In this review, we will discuss the identification, definition and architecture of the WD40 domains. WD40 domain proteins are involved in a large variety of cellular processes, in which WD40 domains function as a protein-protein or protein-DNA interaction platform. WD40 domain mediates molecular recognition events mainly through the smaller top surface, but also through the bottom surface and sides. So far, no WD40 domain has been found to display enzymatic activity. We will also discuss the different binding modes exhibited by the large versatile family of WD40 domain proteins. In the last part of this review, we will discuss how post-translational modifications are recognized by WD40 domain proteins.

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Related Concepts

WD Repeat
Genome
Post-Translational Protein Processing
Tertiary Protein Structure
Staphylococcal Protein A
Protein Structure, Supersecondary
Repetitive Sequences, Amino Acid
Enzymatic Activity [MoA]
Molecular Recognition

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