Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates

Peptides
Nicolas ChartrelHubert Vaudry

Abstract

A number of RFamide peptides have been characterized in invertebrate species and these peptides have been found to exert a broad spectrum of biological activities. In contrast, in vertebrates, our knowledge on RFamide peptides is far more limited and only a few members of the RFamide peptide family have been identified in various vertebrate classes during the last years. The present review focuses on two novel RFamide peptides, Rana RFamide (R-RFa) and 26RFa, that have been recently isolated from the amphibian brain. R-RFa shares the C-terminal LPLRFamide motif with other RFamide peptides previously identified in mammals, birds and fish. The distribution of R-RFa in the frog brain exhibits strong similarities with those of other LPLRFamide peptides, notably in the periventricular region of the hypothalamus. There is also evidence that the physiological functions of R-RFa and other LPLRFamide peptides have been conserved from fish to mammals; in particular, all these peptides appear to be involved in the control of pituitary hormone secretion. 26RFa does not exhibit any significant structural identity with other RFamide peptides and this peptide is the only member of the family that possesses an FRFamide motif at its C-terminus....Continue Reading

References

Aug 12, 1977·Science·D A Price, M J Greenberg
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H Y YangE Costa
Sep 21, 1984·Science·R H SchellerR Taussig
Dec 11, 1981·Science·E WeberJ D Barchas
Jul 1, 1995·The Biochemical Journal·A S GalanopoulouY C Patel
Oct 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·G KochR J Walker
Jan 1, 1996·Peptides·T MuraseY Oiso
Jun 2, 1998·Nature·S HinumaM Fujino
Aug 13, 1998·Journal of Neuroendocrinology·S LabroucheG Simonnet
Jun 14, 2000·The Journal of Biological Chemistry·N A ElshourbagyH M Sarau
Jun 22, 2000·Nature Neuroscience·C B LawrenceS M Luckman
Jul 11, 2000·The Journal of Biological Chemistry·M HosoyaM Fujino
Aug 31, 2000·Biochemical and Biophysical Research Communications·K TsutsuiP J Sharp
Oct 12, 2000·The Journal of Biological Chemistry·J A BoniniB Borowsky
Oct 5, 2001·Biochimica Et Biophysica Acta·S FukusumiM Fujino
Jan 18, 2002·Endocrinology·Catherine B LawrenceSimon M Luckman
Jan 18, 2002·Endocrinology·Kate L J EllacottSimon M Luckman

❮ Previous
Next ❯

Citations

Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Oct 17, 2009·Zoological Science·Takafumi KawaiHeather Eisthen
Feb 18, 2014·Journal of Molecular Endocrinology·Kazuyoshi UkenaKazuyoshi Tsutsui
Aug 8, 2014·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hu ShuHaifa Zhang
Jun 12, 2012·Progress in Neurobiology·Ishwar ParharTakashi Kitahashi
Apr 11, 2009·Biochemical and Biophysical Research Communications·Lei WangChris Shaw
Mar 27, 2007·Progress in Neurobiology·Steven J HussonLiliane Schoofs
May 30, 2006·Peptides·Jean-Claude do RegoJean Costentin
Mar 17, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L MaletínskáJ Kuneš
May 3, 2011·Frontiers in Neuroendocrinology·Nicolas ChartrelCatherine Llorens-Cortes
Dec 30, 2014·Frontiers in Endocrinology·Guro Katrine SandvikFinn-Arne Weltzien
Jul 16, 2016·The Journal of Endocrinology·Jaroslav KunešLenka Maletínská
May 31, 2007·The Journal of Comparative Neurology·Federica BruzzoneNicolas Chartrel
Nov 7, 2007·The Journal of Biological Chemistry·Thomas W Sherwood, Candice C Askwith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.