Structure and hair follicle-specific expression of genes encoding the rat high sulfur protein B2 family

Gene
S MitsuiH Ogawa

Abstract

High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibers in association with hair keratin intermediate filaments. Rat high sulfur protein B2 genes were isolated after screening of a rat genomic library using the cDNA as a probe. Sequence analysis of a 4 kb fragment revealed two high sulfur protein genes, B2E and B2F. Both genes lacked introns, with B2F being located at 2 kb downstream of B2E. The 5' flanking regions of both genes had TATA and CAAT boxes, and consensus sequences of B2 genes. The upstream region of B2F had possible AP-1 and Sp-1 binding elements. The high sulfur protein B2E and B2F, which have putative 188 and 122 amino acids, respectively, comprised four distinct domains with a characteristic repetitive sequence. In situ hybridization indicated that the mRNA of high sulfur protein B2 was specifically localized in the cortex of the hair shaft, and northern blot analysis indicated that the expression of B2 increased in anagen and decreased in telogen, suggesting that high sulfur protein B2 synthesized in cortical cells during anagen contributes to the production of hair fibers.

References

Feb 1, 1992·Trends in Genetics : TIG·M H Hardy
Mar 1, 1990·The Journal of Investigative Dermatology·A P BertolinoD W Yu
Nov 1, 1991·The Journal of Investigative Dermatology·P S KaytesG Vogeli
Dec 26, 1991·Annals of the New York Academy of Sciences·B C PowellG E Rogers
Feb 1, 1989·The Journal of Investigative Dermatology·A R McNabG Vogeli
Jan 1, 1989·Annual Review of Biochemistry·P F Johnson, S L McKnight
Jan 1, 1988·Archives of Dermatological Research·H HammE B Bröcker
Jun 1, 1994·Experimental Cell Research·H WinterJ Schweizer
Sep 1, 1994·The Journal of Investigative Dermatology·B J Jenkins, B C Powell
Jan 1, 1994·Molecular Biology Reports·M A RogersH Winter
Jul 1, 1993·The Journal of Investigative Dermatology·G E Rogers, B C Powell

❮ Previous
Next ❯

Citations

Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Yutaka ShimomuraMasaaki Ito
Feb 14, 2002·The Journal of Investigative Dermatology·Yutaka ShimomuraMasaaki Ito
Jul 21, 2011·Experimental Dermatology·Hua GongJon Hickford
Sep 14, 2002·The Journal of Biological Chemistry·Yutaka ShimomuraMasaaki Ito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.