PMID: 1202413Dec 1, 1975Paper

Structure and invasive behaviour of Plasmodium knowlesi merozoites in vitro

Parasitology
L H BannisterG H Mitchell

Abstract

The structure and invasive behaviour of extracellular erythrocytic merozoites prepared by a cell sieving method have been studied with the electron microscope. Free merozoites contain organelles similar to those described in late schizonts of Plasmodium knowlesi. Their surface is lined by a coat of short filaments. On mixing with fresh red cells, merozoites at first adhere, then cause the red cell surface to invaginate rapidly, often with the formation of narrow membranous channels in the red cell interior. As the merozoite enters the invagination it forms an attachment by its cell coat to the rim of the pit, and finally leaves this coat behind as it is enclosed in a red cell vacuole. Dense, rounded intracellular bodies then move to the merozoite periphery, and apparently rupture to cause further localized invagination of the red cell vacuole. The merozoite finally loses its rhoptries, the pellicle is reduced to a single membrane and the parasite becomes a trophozoite. Invasion is complete by 1 min after adhesion, and the trophozoite is formed by 10 min.

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Citations

Apr 1, 1984·Molecular and Biochemical Parasitology·J A DeansS Cohen
Mar 1, 1988·Molecular and Biochemical Parasitology·G R BushellJ A Cooper
Jan 1, 1989·Molecular and Biochemical Parasitology·J T ClarkJ S McBride
Sep 12, 2001·Molecular and Biochemical Parasitology·M J Blackman, L H Bannister
Jan 30, 2002·Peptides·Marisol OcampoManuel Elkin Patarroyo
May 24, 2003·Trends in Parasitology·Lawrence Bannister, Graham Mitchell
Aug 4, 2009·Parasitology·L H Bannister, G H Mitchell
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robert W MoonMichael J Blackman
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R B MikkelsenR Schmidt-Ullrich
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·M F WiserJ M Favaloro
Dec 3, 2005·PLoS Pathogens·Philippa K HarrisMichael J Blackman
Oct 1, 1991·Research in Immunology·J W Barnwell, M R Galinski
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·R E Sinden
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·S Cohen
Jul 4, 1978·Zeitschrift Für Parasitenkunde·W de Souza, T Souto-Padrón
Dec 1, 1979·Zeitschrift Für Parasitenkunde·R Gothe, E Burkhardt
Nov 1, 1978·The Journal of protozoology·S G LangrethW Trager
Feb 3, 2016·FEMS Microbiology Reviews·James G BeesonJack S Richards
Jul 2, 2011·British Journal of Haematology·Elizabeth S Zuccala, Jake Baum
Feb 11, 2014·Cellular Microbiology·Christof GrüringManoj T Duraisingh

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